H2N2V1, Main, Exploration, bibRecord, 001E53

[Role of individual genes in expression of phenotypic properties of the cold-adapted strain A/Leningrad/134/47/57 (H2N2)-a donor of attenuation of live influenza vaccine].

Identifieur interne : 001E53 ( Main/Exploration ); précédent : 001E52; suivant : 001E54

[Role of individual genes in expression of phenotypic properties of the cold-adapted strain A/Leningrad/134/47/57 (H2N2)-a donor of attenuation of live influenza vaccine].

Auteurs : T E Medvedeva ; V K Kudriavtseva ; G N Nevedomskaia ; I V Zhikhareva ; M I Gushchina ; F N Zolotarev ; G M Vode Ko ; K V Lisovskaia ; V V Iotov ; M I Kha Der

Source :

Genetika [ 0016-6758 ] ; 1993.

RBID : pubmed:8354475

Descripteurs français

KwdFr :
- Acclimatation (physiologie), Animaux, Climat froid, Gènes viraux, Infections à Orthomyxoviridae (), Mâle, Phénotype, Souris, Souris de lignée CBA, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux (génétique), Vaccins atténués (génétique), Virus de la grippe A (génétique).
MESH :
- génétique : Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- physiologie : Acclimatation.
- Animaux, Climat froid, Gènes viraux, Infections à Orthomyxoviridae, Mâle, Phénotype, Souris, Souris de lignée CBA, Sous-type H2N2 du virus de la grippe A.

English descriptors

KwdEn :
- Acclimatization (physiology), Animals, Cold Climate, Genes, Viral, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza Vaccines (genetics), Male, Mice, Mice, Inbred CBA, Orthomyxoviridae Infections (prevention & control), Phenotype, Vaccines, Attenuated (genetics).
MESH :
- chemical , genetics : Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A virus.
- physiology : Acclimatization.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Cold Climate, Genes, Viral, Influenza A Virus, H2N2 Subtype, Male, Mice, Mice, Inbred CBA, Phenotype.

Abstract

The influenza A/Leningrad/134/47/57 (H2N2) (A/Len/47) cold-adapted virus expresses the ability to reproduce at 25 degrees C (the ca phenotype) and inability to reproduce at 40 degrees C (the ts phenotype). It was attenuated for mice. Reassortants of this donor virus with the genes coding for the surface glycoproteins from the epidemic viruses, i.e. hemagglutinin (HA) and neuraminidase (NA), have been shown to be attenuated, immunogenic and genetically stable. We made attempts to reveal the influence of individual genes from the A/Len/47 ca virus on the expression of some phenotypic properties. Different "single-gene" reassortants were created and investigated using the influenza A/PR/8/34 (H1N1) virus as another parent with the opposite phenotypic properties, i.e. lack of ca+ and ts+ phenotypes and high virulence for mice. We managed to obtain "single-gene" reassortants with PB1, NA and NS genes at this stage of the work. None of them (probably including the M gene as well) could determine the ca or ts phenotypes, nor could the presence of the NA and NS genes from the strain A/Len/47 influence these properties. However, our findings show that the combined influence (synergism) of the PB1 and NS genes from the ca donors results in the ts phenotype of the reassortants. Significant role of the NS gene for attenuation of influenza viruses in mice has been revealed.

PubMed: 8354475

Affiliations:

Le document en format XML

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<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza Vaccines (genetics)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred CBA</term>
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<term>Infections à Orthomyxoviridae ()</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Souris</term>
<term>Souris de lignée CBA</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins atténués (génétique)</term>
<term>Virus de la grippe A (génétique)</term>
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<term>Vaccines, Attenuated</term>
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<front><div type="abstract" xml:lang="en">The influenza A/Leningrad/134/47/57 (H2N2) (A/Len/47) cold-adapted virus expresses the ability to reproduce at 25 degrees C (the ca phenotype) and inability to reproduce at 40 degrees C (the ts phenotype). It was attenuated for mice. Reassortants of this donor virus with the genes coding for the surface glycoproteins from the epidemic viruses, i.e. hemagglutinin (HA) and neuraminidase (NA), have been shown to be attenuated, immunogenic and genetically stable. We made attempts to reveal the influence of individual genes from the A/Len/47 ca virus on the expression of some phenotypic properties. Different "single-gene" reassortants were created and investigated using the influenza A/PR/8/34 (H1N1) virus as another parent with the opposite phenotypic properties, i.e. lack of ca+ and ts+ phenotypes and high virulence for mice. We managed to obtain "single-gene" reassortants with PB1, NA and NS genes at this stage of the work. None of them (probably including the M gene as well) could determine the ca or ts phenotypes, nor could the presence of the NA and NS genes from the strain A/Len/47 influence these properties. However, our findings show that the combined influence (synergism) of the PB1 and NS genes from the ca donors results in the ts phenotype of the reassortants. Significant role of the NS gene for attenuation of influenza viruses in mice has been revealed.</div>
</front>
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Serveur d'exploration H2N2

[Role of individual genes in expression of phenotypic properties of the cold-adapted strain A/Leningrad/134/47/57 (H2N2)-a donor of attenuation of live influenza vaccine].

[Role of individual genes in expression of phenotypic properties of the cold-adapted strain A/Leningrad/134/47/57 (H2N2)-a donor of attenuation of live influenza vaccine].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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